Thermo Fisher Scientific Complement C4b Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:5,000

View 1 publication 1 publication

ELISA (ELISA)

1:1,000-1:5,000

-

Product Specifications

Species Reactivity

Human

Published species

Not Applicable

Host/Isotype

Chicken / IgY

Class

Polyclonal

Type

Antibody

Immunogen

Purified human C4b complement protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Complement C4b,uniProtId:P0C0L5-1,ncbiNodeId:9606,antigenRange:1-1744,antigenLength:1744,antigenImageFileName:PA1-9534_Complement_C4b_P0C0L5-1_Chicken.svg,antigenImageFileNamePDP:PA1-9534_Complement_C4b_P0C0L5-1_Chicken_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

IgY fraction

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2066765

Product Specific Information

PA1-9534 detects C4b complement in human samples.

PA1-9534 has been successfully used in Western blot and ELISA procedures. By Western blot, PA1-9534 detects a 88 Kda, 75 Kda, 33 Kda protein representing C4b complement.

PA1-9534 immunogen is a purified human C4b complement protein.

Store product at 4ºC for up to one week and -20ºC for long-term.

Target Information

This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.