Thermo Fisher Scientific Phospho-JAK1 (Tyr1125) Polyclonal Antibody
JAK1 단백질의 Tyr1125 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. 1 mg/mL 농도의 액상 형태로, PBS/glycerol buffer에 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human JAK1 (Accession P23458), corresponding to amino acid residues around phosphorylated Tyr1125. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2816962 |
Product Specific Information
This antibody detects endogenous levels of JAK1 only when phosphorylated at Tyr1125.
Target Information
Janus kinase 1 (JAK1) is a protein tyrosine kinase involved in interferon-alpha/beta and -gamma signal transduction pathways. Upon cytokine or interferon stimulation, JAK1 recruits and phosphorylates Stat transcription factors, which dimerize and translocate to the nucleus to regulate gene transcription. Tyrosine phosphorylation at positions 1022 and 1023 is associated with catalytic activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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