Thermo Fisher Scientific SMC1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human SMC1B for detection of endogenous SMC1L2. Suitable for WB and ICC/IF applications. Affinity purified, unconjugated form, supplied in PBS with glycerol. For research use only.
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- PA5115929
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- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SMC1B (Accession Q8NDV3), corresponding to amino acid residues G1198–R1235 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900563 |
Product Specific Information
Antibody detects endogenous levels of total SMC1L2.
Target Information
Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in nuclear events requiring structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair, and global transcriptional repression. These proteins are conserved in eukaryotes and mutations can lead to mitotic chromosome segregation defects, indicating their essential role in chromosome dynamics. The SMC1 and SMC3 proteins form a heterodimeric complex required for metaphase progression and sister chromatid cohesion. Mutations in this gene are associated with Cornelia de Lange syndrome 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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