Thermo Fisher Scientific DREF Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, Raji
• Predicted reactivity: Rhesus Monkey (99%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

ZBED1, also known as DREF, is the human homolog of the Drosophila DREF protein, a transcriptional regulatory factor required for expression of genes involved in DNA replication and cell proliferation.
RNA interference (RNAi) experiments targeting ZBED1 RNA resulted in inhibition of S phase entry and reduction of histone H1 mRNA in HeLa cells, suggesting a role in cell proliferation.
At least 22 ribosomal proteins possess ZBED1 binding sites in their promoters, and anti-ZBED1 RNAi decreased RP gene expression.
Immunoprecipitation analyses have shown that ZBED1 self-associates in vivo via a carboxyl-terminal hATC domain, required for nuclear localization and DNA binding.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.