Thermo Fisher Scientific Human TTBK2 Synthetic Peptide
인간 TTBK2 단백질의 C-말단 근처 18개 아미노산 서열로 구성된 합성 펩타이드입니다. 항체 PA5-34369의 블로킹 펩타이드로 사용 가능합니다. 정제된 액상 형태로 제공되며, PBS 완충용액에 0.1% BSA와 0.02% sodium azide를 포함합니다. 연구용으로만 사용됩니다.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to an 18 amino acid sequence near the carboxy terminus of human TTBK2.
PEP-1412 can be used as a blocking peptide with polyclonal antibody PA5-34369.
Target Information
Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem.
Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increase resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 through the use of siRNA sensitizes these cell lines to the effects of Sunitinib. This suggests that TTBK2 can serve as a resistance marker as well as a potential therapeutic target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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