Thermo Fisher Scientific PCDHA8 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
PCLPPDLGSV DVGEEQDLNV DHGLKVSPFK FRTHKFYLWK L

Antigen sequence identity:

• Mouse: 34%
• Rat: 35%

Target Information

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters.
The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons (variable exons) are followed by downstream C-terminal exons (constant exons), which are shared by all genes in the cluster.
The large, uninterrupted N-terminal exons each encode six cadherin ectodomains, while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that likely play a critical role in the establishment and function of specific cell-cell connections in the brain.
Alternative splicing has been observed, and additional variants have been suggested, but their full-length nature has yet to be determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.