Thermo Fisher Scientific CDNF Polyclonal Antibody
CDNF 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(P)에서 검증됨. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 안정성을 제공. 파킨슨병 연구 등 도파민 신경영양 인자 관련 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CDNF. Recombinant protein control fragment (Product #RP-97191). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639618 |
Product Specific Information
Immunogen sequence:
TLDLASVDLR KMRVAELKQI LHSWGEECRA CAEKTDYVNL IQELAPKYAA TH
Highest antigen sequence identity to orthologs:
- Mouse: 81%
- Rat: 85%
Target Information
The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neurotrophic factor. CDNF is expressed at higher levels in tissues such as heart, skeletal muscle, and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent 6-hydroxylamine (6-OHDA)-induced degeneration of dopaminergic neurons in a rat model of Parkinson’s disease. Furthermore, CDNF was able to restore dopaminergic function and prevent degeneration of dopaminergic neurons in the substantia nigra, suggesting potential use in Parkinson’s disease research. At least two isoforms of CDNF are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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