Thermo Fisher Scientific eIF3b Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody is predicted to react with mouse, rat, cow, and fruit fly (Drosophila melanogaster) based on sequence homology.

Target Information

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:9388245, PubMed:17581632, PubMed:25849773, PubMed:27462815).
The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC).
It stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition, and is also required for disassembly and recycling of post-termination ribosomal complexes.
The eIF-3 complex prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation and specifically targets translation of mRNAs involved in cell proliferation, differentiation, and apoptosis.
[Source: UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.