Thermo Fisher Scientific SCD Polyclonal Antibody
Human 및 Mouse 시료에 반응하는 Rabbit Polyclonal SCD 항체로, WB, ICC/IF, IP에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS(pH 7.4, 1% BSA) 용액 형태로 제공. 세포막 유동성 및 신호전달 관련 연구에 적합. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 2 µg/mL | View 2 publications |
| Immunocytochemistry (ICC/IF) | 5–10 µg/mL | – |
| Immunoprecipitation (IP) | – | View 1 publication |
| Miscellaneous PubMed (Misc) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH derived from within residues 50–150 of Human SCD |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.9 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10982251 |
Product Specific Information
This antibody is predicted to react with mouse based on sequence homology.
Target Information
Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an iron-containing enzyme that catalyzes a rate-limiting step in the synthesis of unsaturated fatty acids. The principal product of SCD is oleic acid, which is formed by desaturation of stearic acid. The ratio of stearic acid to oleic acid has been implicated in the regulation of cell growth and differentiation through effects on cell membrane fluidity and signal transduction.
Four SCD isoforms (Scd1–Scd4) have been identified in mouse, while two isoforms (SCD1 and SCD5) have been identified in human. SCD1 shares about 85% amino acid identity with all four mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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