Thermo Fisher Scientific mGluR5 Polyclonal Antibody
Thermo Fisher Scientific의 mGluR5 Polyclonal Antibody는 인간 mGluR5 단백질을 인식하는 sheep 유래 IgG 항체로, WB 및 IHC에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA547630
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 0.1 µg/mL
Immunohistochemistry (IHC)
- Tested Dilution: 5–15 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant human mGluR5 (Gln21–Ser509) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2608805 |
Product Specific Information
- In direct ELISAs and Western blots, approximately 20% cross-reactivity with recombinant human (rh) mGluR1 is observed.
- Less than 5% cross-reactivity with rhmGluR2 and rhmGluR3 is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
GRK1 is a member of the guanine nucleotide protein-coupled receptor kinase (G protein receptor kinase) subfamily of the Serine/Threonine kinase family.
GRK1 phosphorylates rhodopsin and initiates its deactivation. G protein-mediated phosphorylation promotes arrestin binding, which removes the receptor from the G-protein and terminates the receptor signal chain.
GRK1 is farnesylated to promote membrane association. Studies have shown that GRK1 can be inhibited by recoverin, a calcium-binding protein.
Diseases associated with GRK1 dysfunction include Oguchi Disease-2 and Hereditary Night Blindness.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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