Thermo Fisher Scientific mGluR5 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1 µg/mL

Immunohistochemistry (IHC)

• Tested Dilution: 5–15 µg/mL

Product Specifications

Product Specific Information

• In direct ELISAs and Western blots, approximately 20% cross-reactivity with recombinant human (rh) mGluR1 is observed.
• Less than 5% cross-reactivity with rhmGluR2 and rhmGluR3 is observed.
• Reconstitute at 0.2 mg/mL in sterile PBS.

Target Information

GRK1 is a member of the guanine nucleotide protein-coupled receptor kinase (G protein receptor kinase) subfamily of the Serine/Threonine kinase family.
GRK1 phosphorylates rhodopsin and initiates its deactivation. G protein-mediated phosphorylation promotes arrestin binding, which removes the receptor from the G-protein and terminates the receptor signal chain.
GRK1 is farnesylated to promote membrane association. Studies have shown that GRK1 can be inhibited by recoverin, a calcium-binding protein.
Diseases associated with GRK1 dysfunction include Oguchi Disease-2 and Hereditary Night Blindness.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.