Thermo Fisher Scientific Human EGFR (ErbB1) [L858R], GST Tag Recombinant Protein

Applications

• Kinase Assay (KA): Assay-dependent

Product Specifications

Product Specific Information

• For maximum recovery, please spin prior to use.
• Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use material in original packaging until exhausted.
• For larger sizes, aliquots may be prepared to reduce freeze/thaw cycles (do not prepare aliquots below 20 µL).
• Never store kinase diluted.
• Properly stored at -80°C, product is guaranteed for 6 months from date of purchase.
• Protein Form: Cytoplasmic

Target Information

EGFR (epidermal growth factor receptor) is a receptor tyrosine kinase that signals in response to various growth factors. Overexpression has been linked to numerous types of cancer, making EGFR a key target for biological and small molecule therapeutics.
The EGFR gene is located on chromosome 7 in humans and belongs to the HER/ErbB family, which includes ERbB2, ERbB3, and ERbB4.
EGFR is a transmembrane receptor; binding of ligands such as EGF and TGF-α to its extracellular domain induces dimerization and autophosphorylation of tyrosine residues in the cytoplasmic domain.
Overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, and in squamous cell carcinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.