Thermo Fisher Scientific Human Precerebellin Synthetic Peptide

Thermo Fisher Scientific Human Precerebellin Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 16 amino acids near the carboxy terminus of human Precerebellin.
PEP-0278 can be used as a blocking peptide with polyclonal antibody PA5-20159.

Target Information

Precerebellin is the precursor of the brain-specific hexadecapeptide cerebellin, a protein with substantial similarity to the globular region of the B chain of complement component C1q. Cerebellin exerts neuromodulatory functions by directly stimulating norepinephrine release via the adenylate cyclase/pka-dependent signaling pathway, and indirectly enhances adrenocortical secretion in vivo through a paracrine mechanism involving medullary catecholamine release.
The active form of precerebellin is highly enriched in postsynaptic structures of cerebellar Purkinje cells and cartwheel neurons of the dorsal cochlear nucleus.
Because precerebellin belongs to the C1q/tumor necrosis factor superfamily of secreted proteins and has similarity to adiponectin and CTRP3, it has been suggested that precerebellin possesses additional functions beyond those already stated.

Usage Notes

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.