Thermo Fisher Scientific beta-2 Microglobulin Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended positive controls: A431, mouse plasma, rat plasma, HeLa, B2M shRNA-transfected HeLa, marmoset rProtein
• Predicted reactivity: Rhesus Monkey (92%), Chimpanzee (100%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Beta-2-microglobulin (B2M) is a 12–14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I.
Human beta-2 Microglobulin associated with HLA Class I antigens is expressed on many cell types including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes.
It is also found in free form in plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta-pleated sheet structure.
The protein is ubiquitously expressed in the cytoplasm and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling and downstream signaling in naive CD8+ cells.
The B2M gene is located on chromosome 15, and mutations can result in hypercatabolic hypoproteinemia.
Levels of beta-2 microglobulin can be used to assess renal function in kidney transplant recipients and as a prognostic marker for HIV infection.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.