Thermo Fisher Scientific beta-2 Microglobulin Polyclonal Antibody
Western blot, IHC, ICC, IP 등 다양한 응용에 적합한 beta-2 Microglobulin 폴리클로날 항체. Human, Mouse, Rat 등 반응성. 항원 친화 크로마토그래피로 정제된 고순도 항체. PBS 기반 안정화 용액에 보관, 연구용 전용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
| Immunoprecipitation (IP) | 1:100–1:500 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Full length human beta-2 Microglobulin recombinant protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.37 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS (pH 7) with 1% BSA, 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547056 |
Product Specific Information
- Recommended positive controls: A431, mouse plasma, rat plasma, HeLa, B2M shRNA-transfected HeLa, marmoset rProtein
- Predicted reactivity: Rhesus Monkey (92%), Chimpanzee (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Beta-2-microglobulin (B2M) is a 12–14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I.
Human beta-2 Microglobulin associated with HLA Class I antigens is expressed on many cell types including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes.
It is also found in free form in plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta-pleated sheet structure.
The protein is ubiquitously expressed in the cytoplasm and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling and downstream signaling in naive CD8+ cells.
The B2M gene is located on chromosome 15, and mutations can result in hypercatabolic hypoproteinemia.
Levels of beta-2 microglobulin can be used to assess renal function in kidney transplant recipients and as a prognostic marker for HIV infection.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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