Thermo Fisher Scientific H1FOO Polyclonal Antibody
H1FOO 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간 및 랫트 시료에 반응합니다. Western blot과 면역세포염색에 사용 가능하며, 고순도 친화 크로마토그래피로 정제되어 안정적인 결과를 제공합니다. 연구용으로만 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human H1FOO (Accession Q8IZA3), corresponding to amino acid residues P137–P187 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853850 |
Product Specific Information
Antibody detects endogenous levels of total Histone H1.
Target Information
Eukaryotic histones are basic, water-soluble nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA into a left-handed super-helical turn, forming chromosomal fibers.
Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form the octamer, consisting of two H2A-H2B dimers and two H3-H4 dimers with nearly symmetrical tertiary structures.
Over 80% of nucleosomes contain the linker histone H1, derived from an intronless gene, which interacts with linker DNA between nucleosomes and mediates chromatin compaction.
H1FOO (H1 histone family, member O, oocyte-specific), also known as OSH1, is a 346-amino-acid oocyte-specific histone localized to both the nucleus and cytoplasm. Expressed as multiple alternatively spliced isoforms, H1FOO plays an important role in gene regulation during oogenesis and early embryogenesis and is crucial for meiotic maturation of germinal vesicle-stage oocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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