Thermo Fisher Scientific NKp44 Polyclonal Antibody
Thermo Fisher Scientific의 NKp44 Polyclonal Antibody는 인간 NKp44(NCR2)를 인식하는 Rabbit Polyclonal 항체입니다. Western blot 및 IHC(P)에서 검증되었으며, Affinity chromatography로 정제되었습니다. 액상 형태로 제공되며, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NCR2 (Accession O95944), corresponding to amino acid residues T136–G186. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2853287 |
Product Specific Information
Antibody detects endogenous levels of total NCR2.
Target Information
CD336, also known as NKp44 or NCR2, is a 44-kDa transmembrane glycoprotein belonging to the natural cytotoxicity receptor (NCR) family and contains an ITIM domain located in the cytoplasmic tail. Expression of CD336 and NK cell activation by the receptor requires association with DAP12, an ITAM-containing transmembrane accessory protein.
CD336 was initially thought to be expressed exclusively on IL-2-activated NK cells and a subset of gamma delta T lymphocytes. However, studies have shown expression on IL-3-stimulated plasmacytoid dendritic cells, alpha beta T cells in the small intestinal epithelium, and T cells in cord blood. CD336 plays a role in the innate response of activated NK cells against viral infection and tumor cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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