Thermo Fisher Scientific CD3e Monoclonal Antibody (500A2), FITC

Applications

Flow Cytometry (Flow)

• Tested Dilution: 0.1–0.25 µg / 1×10⁶ cells
• View 8 publications

Neutralization (Neu)

• Tested Dilution: –
• View 1 publication

Miscellaneous PubMed (Misc)

• Tested Dilution: –
• View 10 publications

Product Specifications

Additional Formats

• Alexa Fluor 488 (HM3420)
• Alexa Fluor 647 (HM3421)
• Pacific Blue (HM3428)
• Request custom conjugation

Target Information

The CD3 subunit complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of CD3 subunits (gamma, delta, epsilon, zeta), which are structurally related members of the immunoglobulin superfamily encoded on human chromosome 11.

CD3 subunits have long cytoplasmic tails that associate with signal transduction molecules, mediated by a double tyrosine-based motif. CD3 may play a role in TCR-induced growth arrest, cell survival, and proliferation. The CD3 antigen is expressed on 68–82% of normal peripheral blood lymphocytes, 65–85% of thymocytes, and Purkinje cells in the cerebellum, but not on B or NK cells. Decreased T lymphocyte percentages may be observed in autoimmune diseases. Defects in the CD3 gene are associated with CD3 immunodeficiency.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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