Thermo Fisher Scientific RBP3 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:1,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Keep as concentrated solution.
• Predicted reactivity: Mouse (87%), Rat (85%), Bovine (85%).
• Centrifuge briefly prior to opening the vial.

Target Information

Interphotoreceptor retinol-binding protein (IRBP) is a large glycoprotein that binds retinoids and is found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and photoreceptor cells.
It is thought to transport retinoids between these cell layers, playing a critical role in the visual process.
The human IRBP gene (~9.5 kbp) consists of four exons separated by three introns (1.6–1.9 kbp). The mRNA (~4.3 kb) encodes a glycosylated protein of 135 kDa.
The amino acid sequence divides into four contiguous homology domains (33–38% identity), suggesting gene duplication events.
The first three domains and part of the fourth are encoded by the first large exon (3,180 bp), while the remainder of the fourth domain is encoded in the last three exons (191, 143, and ~740 bp).

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.