Thermo Fisher Scientific p38 MAPK alpha Monoclonal Antibody (9F12), APC

Thermo Fisher Scientific p38 MAPK alpha Monoclonal Antibody (9F12), APC

Applications and Tested Dilutions

Product Specifications

Available Formats

• FITC conjugate (Cat. MA5-45193)
• PerCP conjugate (Cat. MA5-45194)
• Custom conjugation available upon request

Product Specific Information

Detects approximately 38 kDa protein corresponding to p38 alpha MAPK when loaded with 6 ng of purified p38 alpha by chemiluminescent immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody. Detects approximately 38 kDa.

Target Information

MAPK14 (p38 alpha) is a member of the stress-activated protein kinase class of MAPKs. The p38 MAPK cascade regulates various cellular responses to stress, inflammation, and other signals. p38 MAPK is relatively inactive in the nonphosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motif. There are four isoforms of p38 MAPK, differing in tissue expression and affinity for upstream activators and downstream effectors. When cells are exposed to tumor necrosis factor, interleukin-1, heat shock, or other activating stimuli, activation of MAPK kinase-3 occurs by phosphorylation. Activated MAPK kinase-3/6 phosphorylates Thr180 and Tyr182 residues in p38 MAPK. Phospho-p38 MAPK activates ATF-2, CHOP-1, MEF-2, and other transcription factors through phosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지