Thermo Fisher Scientific CD42b Monoclonal Antibody (SZ2)
CD42b 단클론 항체(SZ2)는 인간 혈소판 표면 단백질을 인식하는 Mouse IgG1 항체로, 응고 및 혈소판 활성화 연구에 적합합니다. Flow Cytometry에 사용 가능하며, 단백질 A로 정제된 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
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Applications
- Flow Cytometry (Flow): Tested Dilution 2 µg
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SZ2 |
| Immunogen | Human washed platelets |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 0.1% BSA |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_558202 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
CD42b is a platelet activation marker involved in coagulation as an aggregating factor. It interacts with extracellular matrix and adhesion molecules. CD42b expression and activation are regulated by VEGF and PDGF. Together with GPIb beta, GPIX, and GPV, CD42b forms the GPIb-IX-V receptor complex, critical for platelet-rich thrombus formation by tethering platelets to thrombogenic surfaces. CD42b binds to von Willebrand factor (VWF), thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1, and P-selectin. Its extracellular domain contributes to metastasis. CD42b antigen is expressed on platelets and megakaryocytes in bone marrow. Mutations in CD42b are associated with Bernard-Soulier syndrome and platelet-type von Willebrand disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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