Thermo Fisher Scientific Beta crystallin S Polyclonal Antibody, FITC

Applications and Tested Dilutions

Product Specifications

Target Information

Crystallins are separated into two classes: taxon-specific (enzyme) and ubiquitous. The ubiquitous class constitutes the major proteins of the vertebrate eye lens, maintaining transparency and refractive index. Lens central fiber cells lose their nuclei during development, so crystallins are produced and retained throughout life, making them extremely stable proteins.

Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered a superfamily. Alpha and beta families are further divided into acidic and basic groups. Crystallins have seven protein regions: four homologous motifs, a connecting peptide, and N- and C-terminal extensions.

Gamma-crystallins are homogeneous, monomeric proteins typically lacking connecting peptides and terminal extensions, and are differentially regulated after early development. The gene encoding Beta crystallin S was initially considered to produce a beta-crystallin, but the protein is monomeric and shares greater sequence similarity with gamma-crystallins. It encodes the predominant gamma-crystallin in adult eye lens tissue. Mutations or aging-related changes in gamma-crystallins are associated with cataract formation.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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