Thermo Fisher Scientific TLR7 Polyclonal Antibody
TLR7 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 폴리클로날 항체. Western blot, IHC, Flow Cytometry 등 다양한 응용에 사용 가능. 인간 시료 반응성. 동결건조 형태로 제공되며, 장기 보관 시 -20°C 권장. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Flow Cytometry (Flow) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Goat / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the extracellular domain of human TLR7 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: TLR7.
Target Information
TLR7 is a highly conserved membrane protein belonging to the Toll-like receptor (TLR) family, characterized by 27 leucine-rich repeats (LRR) and a TIR domain. It plays a key role in pathogen recognition and activation of innate immunity.
TLR7 is activated by single-stranded RNA viruses such as influenza and vesicular stomatitis virus (VSV). It is predominantly expressed in lung, placenta, and spleen, and is located near TLR8.
Through MyD88 and TRAF6, TLR7 signaling leads to NF-kappaB activation, cytokine secretion, and inflammatory response. It recognizes pathogen-associated molecular patterns (PAMPs) on infectious agents and mediates cytokine production essential for effective immunity.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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