Thermo Fisher Scientific alpha-1 Antitrypsin Polyclonal Antibody
Thermo Fisher Scientific의 alpha-1 Antitrypsin Polyclonal Antibody는 쥐 및 랫트 시료에 반응하며, Western blot 및 IHC(P) 분석에 적합합니다. 항원 친화 크로마토그래피로 정제된 Rabbit IgG 폴리클로날 항체로, 단백질 억제 연구 및 염증 관련 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.5–1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E.coli-derived rat SERPINA1 recombinant protein (Position: K211–R411) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5 mg BSA |
| Contains | 0.05 mg sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2747089 |
Product Specific Information
- Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
Alpha-1-AT is synthesized in the liver and acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung.
In the absence of alpha-1-AT, these enzymes are not inhibited and may digest pulmonary parenchyma.
Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and, less frequently, hepatic cirrhosis in infants and respiratory distress of the newborn.
Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum levels of alpha-1-AT are elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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