Thermo Fisher Scientific IL-17A Monoclonal Antibody (4H1524.1)
인간 IL-17A 단백질을 특이적으로 인식하는 Mouse IgG2b 단클론 항체. Western blot, Flow cytometry, ELISA 등에 사용 가능. 비접합 형태로 제공되며, 단백질 G로 정제된 액상 제품. -20°C에서 안정적으로 보관 가능.
- 카탈로그번호
- 209-301-B32x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IL-17A Monoclonal Antibody (4H1524.1)
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | 1:10,000–1:50,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4H1524.1 |
| Immunogen | Produced in mouse by repeated immunizations with mature full-length recombinant human IL-17A (E. coli expression), followed by hybridoma development. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | 0.02 M potassium phosphate, pH 7.2, with 0.15 M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Product Specific Information
Store vial at -20°C prior to opening.
Aliquot contents and freeze at -20°C or below for extended storage.
Avoid cycles of freezing and thawing.
Centrifuge product if not completely clear after standing at room temperature.
Stable for several weeks at 4°C as an undiluted liquid.
Dilute only prior to immediate use.
This antibody is specific for human IL-17A protein.
BLAST analysis suggests 100% homology with human IL-17A immunizing sequence.
Cross-reactivity with IL-17A from other species has not been determined.
Target Information
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection.
IL-17A is a 32 kDa disulfide-linked homodimer of 136 amino acids, part of the IL-17A–F family, signaling through IL-17R/CDw217.
It induces expression of ICAM-1, IL-6, IL-8, G-CSF, and PGE2, and supports proliferation of CD34+ hematopoietic progenitors.
IL-17A regulates NF-κB and MAPK pathways, stimulates COX-2 and nitric oxide production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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