Thermo Fisher Scientific RIP3 Polyclonal Antibody
RIP3 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체로, WB, IHC, ICC, IP 등 다양한 응용에 적합합니다. Mouse와 Rat에서 반응하며, 항원 친화 크로마토그래피로 정제된 액상 형태입니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific RIP3 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL | View 3 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–5 µg/mL | – |
| Immunocytochemistry (ICC/IF) | – | View 1 publication |
| Immunoprecipitation (IP) | 20 µg/mL | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A peptide corresponding to 14 amino acids near the carboxy terminus of murine RIP3. The immunogen is located within the last 50 amino acids of RIP3. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154832 |
Product Specific Information
- Suggested positive controls: Rat Thymus Lysate, 3T3/NIH Cell Lysate, or C2C12 Cell Lysate
- PA5-19956 can be used with blocking peptide PEP-0081
Target Information
RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, containing a unique C-terminal domain. It is predominantly localized to the cytoplasm and mitochondria, capable of nucleocytoplasmic shuttling via nuclear localization and export signals. RIPK3 is part of the TNF receptor-I signaling complex and can induce apoptosis while weakly activating NF-kappaB. Caspase-8 prevents RIPK3-dependent necrosis by forming a proteolytically active complex with CFLAR, essential for its protective function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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