Thermo Fisher Scientific CD9 Monoclonal Antibody (HI9a)
CD9 단백질을 인식하는 HI9a 클론 단일클론 항체로, 인간 시료에 반응합니다. IHC(P)와 유세포분석(Flow Cytometry)에 적합하며, 세포막 단백질 연구에 활용됩니다. 비결합형 액상 형태로 제공되며, 단백질 A로 정제되어 안정적입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
| Flow Cytometry (Flow) | 0.5–5 µg/10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HI9a |
| Immunogen | Recombinant protein of human CD9 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Thymus
- Cellular location: Membrane
Target Information
CD9 antigen is a glycoprotein expressed on the surface of developing B lymphocytes, platelets, monocytes, eosinophils, basophils, stimulated T lymphocytes, and by neurons and glial cells in the peripheral nervous system.
CD9 belongs to the tetraspanin family, transversing the membrane four times. In pre-B cells and platelets, CD9 regulates cell activation and aggregation, possibly through association with integrin CD41/CD61 (GPIIb/GPIIIa).
It is involved in cell motility, osteoclastogenesis, neurite outgrowth, myotube formation, and sperm-egg fusion. CD9 plays roles in cell attachment and proliferation and is necessary for association of heterologous MHC II molecules on dendritic cell membranes, important for effective T cell stimulation.
CD9 functions in differentiation, adhesion, and signal transduction, and its expression plays a critical role in suppressing cancer cell motility and metastasis. CD9 is also considered a metastasis suppressor in solid tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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