Thermo Fisher Scientific CD7 Monoclonal Antibody (H1T7)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 2–10 µg/mL

Flow Cytometry (Flow)

• Tested Dilution: 0.5–5 µg/10^6 cells

Product Specifications

Product Specific Information

• Positive control: Thymus
• Cellular location: Membrane

Target Information

CD7 (gp40, Leu9) is a 40 kDa member of the immunoglobulin gene superfamily. The N-terminal amino acids (1–107) are highly homologous to Ig kappa-L chains, whereas the carboxy-terminal region of the extracellular domain is proline-rich and may form a stalk projecting the Ig domain.
CD7 is expressed on most immature and mature T-lymphocytes and T cell leukemia cells. It is also present on natural killer cells, a small subset of normal B cells, and malignant B cells.
Cross-linking surface CD7 positively modulates T cell and NK cell activity, influencing calcium fluxes, adhesion molecule expression, cytokine secretion, and proliferation. CD7 associates directly with phosphoinositol 3′-kinase, and its ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.
Expression of CD7 serves as an important marker in leukemia diagnostics.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.