Thermo Fisher Scientific LDLRAD4 Polyclonal Antibody
LDLRAD4 단백질을 인식하는 Rabbit Polyclonal 항체로, 인간 시료에 반응합니다. IHC(P)에서 1:1,000~1:2,500 희석으로 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. TGF-beta 신호 조절 연구에 적합합니다.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1:1,000–1:2,500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human LDLRAD4 (UniProt ID: O15165-1, antigen range: 88–156, antigen length: 306) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.6 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2643328 |
Product Specific Information
Immunogen sequence:
HYKVSTRSFI NRPNQSRRRE DGLPQEGCLW PSDSAAPRLG ASEIMHAPRS RDRFTAPSFI QRDRFSRFQ
Sequence identity:
- Mouse: 81%
- Rat: 81%
Target Information
LDLRAD4 functions as a negative regulator of TGF-beta signaling and may play roles in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production, and immunosuppression.
In the canonical TGF-beta pathway, ZFYVE9/SARA recruits SMAD2 and SMAD3 to the TGF-beta receptor. After phosphorylation, SMAD2/3 form a complex with SMAD4 that translocates to the nucleus to regulate transcription.
LDLRAD4 interacts with SMAD2 and SMAD3, potentially competing with ZFYVE9 and SMAD4, thereby inhibiting signal propagation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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