Thermo Fisher Scientific Phospho-PKA alpha/beta/gamma (Thr198) Polyclonal Antibody
PKA alpha/beta/gamma 단백질의 Thr198 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot 및 IHC에 적합하며, 인산화 상태 분석에 유용. 1 mg/mL 농도의 액상 형태로, -20°C에서 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
- View 1 publication
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
- View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PRKACA (Accession P17612), corresponding to amino acid residues around phosphorylated Thr198 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816943 |
Product Specific Information
Antibody detects endogenous levels of PKA alpha/beta/gamma catalytic subunit only when phosphorylated at Thr198.
Target Information
Protein kinase A (PKA, cAMP-dependent protein kinase) is a key element of a ubiquitous signaling pathway important in the cell cycle, cellular communication, memory formation, and behavior.
PKA consists of two catalytic (PKAc) and two regulatory (PKAr) subunits. Upon binding cAMP, the complex dissociates into a PKAr dimer and two activated PKAc ser/thr protein kinase catalytic monomers.
Activated PKAc can translocate into the nucleus and regulate multiple nuclear hormone receptors.
Humans express three types of PKAc subunit:
- PKAc alpha (present in most tissues)
- PKAc beta (tissue-specific)
- PKAc gamma (found in testes)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-105515_PKA_alphabetagamma_P17612-1_Rabbit.svg)
(이미지: PA5-105515_PKA_alphabetagamma_P17612-1_Rabbit_PDP.jpeg)
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