Thermo Fisher Scientific MYH9 Polyclonal Antibody
MYH9 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot 및 Immunocytochemistry에 최적화되어 있으며, Human, Mouse, Rat에 반응. 비보존제 액상 형태로 -20°C에서 보관. MYH9 관련 질환 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 2 publications |
| Immunocytochemistry (ICC/IF) | 1:50 | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Dog, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the carboxy terminus of mouse myosin IIa |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 20 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10984569 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with the nonmuscle heavy chains of myosin IIb or IIc.
Target Information
The MYH9 gene, located on chromosome 22q12.3, encodes the heavy chain of non-muscle myosin IIA (NMHC IIA), a critical component of the actin cytoskeleton involved in cell migration, adhesion, division, and shape maintenance.
It spans over 106 kilobases and includes 41 exons encoding a 1,960 amino acid protein that forms a hexameric complex with two heavy chains, two regulatory light chains, and two essential light chains.
Mutations in MYH9 cause autosomal dominant disorders known as MYH9-related diseases (MYH9-RD), including May-Hegglin anomaly, Fechtner syndrome, and Epstein syndrome, characterized by macrothrombocytopenia and sometimes hearing loss, renal failure, and cataracts.
MYH9 function is essential for hematopoietic stem and progenitor cell maintenance; its loss leads to blood cell deficiencies and bone marrow failure.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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