Thermo Fisher Scientific CDT1 Polyclonal Antibody
Thermo Fisher Scientific의 CDT1 Polyclonal Antibody는 인간 CDT1 단백질의 N-말단 서열에 대응하는 합성 펩타이드로 제작된 토끼 IgG 항체입니다. Western blot에 적합하며, 비결합형 액상 형태로 제공됩니다. -20°C에서 보관하며 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA517024
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the amino terminal sequence of human CDT1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10982810 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
KMT2A is a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of Lys-4 of histone H3 (H3K4me) and acetylation of Lys-16 of histone H4 (H4K16ac). In the MLL1/MLL complex, KMT2A specifically mediates H3K4me, a tag for epigenetic transcriptional activation. KMT2A has weak methyltransferase activity by itself and requires other components of the MLL1/MLL complex to obtain full methyltransferase activity. It has no activity toward histone H3 phosphorylated on Thr-3, less activity toward H3 dimethylated on Arg-8 or Lys-9, and higher activity toward H3 acetylated on Lys-9. Required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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