Thermo Fisher Scientific ST2 Polyclonal Antibody
Thermo Fisher Scientific의 ST2 Polyclonal Antibody는 인간 및 생쥐 시료에서 ST2 단백질을 검출하는 토끼 다클론 항체입니다. Western blot 및 면역조직화학에 적합하며, 고순도의 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human IL1RL1 (Accession Q01638), corresponding to amino acid residues A365–Y415 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2899416 |
Product Specific Information
This antibody detects endogenous levels of total ST2.
Target Information
IL-33R, also known as ST2, is a receptor for IL-33 and a member of the IL-1 receptor family of innate receptors. Its extracellular domain consists of three Ig-like domains that interact with the co-receptor IL-1RAcP and ligand IL-33. IL-33 binding activates adaptor proteins (MyD88, IRAK1, IRAK4, TRAF6), leading to NF-κB and MAPK pathway activation and the release of cytokines such as IL-5, IL-6, IL-8, and IL-13.
Two main isoforms of IL-33R exist:
- ST2L: membrane-bound form, can be released by proteolytic cleavage
- ST2S: soluble form acting as a decoy receptor
IL-33R is primarily expressed by mast cells, basophils, and eosinophils, and in mice, also by ILC2 and Th2 cells. IL-33R signaling is implicated in immune conditions such as allergies, arthritis, atherosclerosis, and sepsis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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