Thermo Fisher Scientific Laminin gamma-1 Polyclonal Antibody
Thermo Fisher Scientific의 Laminin gamma-1 Polyclonal Antibody는 인간 Laminin γ1 단백질을 인식하는 토끼 유래 다클론 항체로, Western blot 및 IHC(파라핀 절편)에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관됩니다.
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- PA581991
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human LAMC1. Recombinant protein control fragment (Product #RP-101883) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789152 |
Product Specific Information
Immunogen sequence:
ECREGFVGNR CDQCEENYFY NRSWPGCQEC PACYRLVKDK VADHRVKLQE LESLIANLGT GDEMVTDQAF EDRLKEAERE VMDLLREAQD VKDVDQNLMD RLQRVNNTLS SQISRLQNIR NTIEETGNLA EQARAHVENT ERLIEIASR
Target Information
Laminins are essential and abundant structural non-collagenous glycoproteins localizing to basement membranes. Basement membranes (cell-associated extracellular matrices, ECMs) are polymers of Laminins with stabilizing Type IV Collagen networks, Nidogen, and several proteoglycans.
They are found under epithelial layers, around the endothelium of blood vessels, and surrounding muscle, peripheral nerve, and fat cells.
Formation of basement membranes influences cell proliferation, phenotype, migration, gene expression, and tissue architecture.
Each Laminin is a heterotrimer of alpha, beta, and gamma chain subunits that undergo cell secretion and incorporation into the ECM. Laminins can self-assemble, bind to other matrix macromolecules, and have unique and shared cell interactions mediated by Integrins, dystroglycan, and cognate Laminin receptors.
The human Laminin gamma-1 gene maps to chromosome 1q31 and is ubiquitously expressed in tissues that produce basement membranes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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