Thermo Fisher Scientific Phospho-Androgen Receptor (Ser213) Polyclonal Antibody

Thermo Fisher Scientific Phospho-Androgen Receptor (Ser213) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Suggested positive control for Western blot: DU145 cells
• Suggested positive control for ICC/IF: HeLa cells

Target Information

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, the receptor translocates into the nucleus, dimerizes, and activates transcription of androgen-responsive genes.

AR signaling plays a key role in development and function of male reproductive organs such as the prostate and epididymis, as well as nonreproductive organs including muscle, hair follicles, and brain. It is a phosphoprotein that regulates MAP kinase activity, and its phosphorylation state is linked to MEK1/2 pathway activity. Dysregulation of AR signaling is associated with diseases such as prostate cancer, Kennedy’s disease, and male infertility. Mutations in the AR gene can cause complete androgen insensitivity (CAIS).

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.