Thermo Fisher Scientific Phospho-Androgen Receptor (Ser213) Polyclonal Antibody
인간 Androgen Receptor의 Ser213 인산화 부위를 인식하는 Rabbit Polyclonal Antibody로, WB 및 ICC/IF에 사용 가능. 1 mg/mL 농도의 액상 형태이며, PBS/glycerol buffer에 보관. DU145 및 HeLa 세포를 양성 대조군으로 권장.
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Thermo Fisher Scientific Phospho-Androgen Receptor (Ser213) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of serine 213 (E-A-S(p)-G-A) derived from Human Androgen Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2554087 |
Product Specific Information
- Suggested positive control for Western blot: DU145 cells
- Suggested positive control for ICC/IF: HeLa cells
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, the receptor translocates into the nucleus, dimerizes, and activates transcription of androgen-responsive genes.
AR signaling plays a key role in development and function of male reproductive organs such as the prostate and epididymis, as well as nonreproductive organs including muscle, hair follicles, and brain. It is a phosphoprotein that regulates MAP kinase activity, and its phosphorylation state is linked to MEK1/2 pathway activity. Dysregulation of AR signaling is associated with diseases such as prostate cancer, Kennedy’s disease, and male infertility. Mutations in the AR gene can cause complete androgen insensitivity (CAIS).
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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