Thermo Fisher Scientific beta-1, beta-1-Adrenoceptor Polyclonal Antibody
Rabbit polyclonal antibody recognizing human beta-1 adrenergic receptor. Validated for Western blot (1:1,000). Supplied as liquid, 1 mg/mL, purified by antigen affinity chromatography. Store at 4°C short term or -20°C long term. For research use only.
- 카탈로그번호
- 7TM0028N
- 판매단위
- pk
카탈로그
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Applications
- Western Blot (WB): 1:1,000 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from human beta 1 with the sequence GPPPSPGAAS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | Dulbecco’s PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Adrenergic receptors (ARs) belong to the 7-transmembrane domain G-protein-coupled receptor superfamily that binds endogenous catecholamines epinephrine and norepinephrine.
Nine receptor subtypes have been identified: three alpha-1 (1A/D, 1B, 1C), three alpha-2 (2A, 2B, 2C), and three beta (1, 2, 3).
ARs are involved in various physiological and pathological processes including:
- Hypertension
- Cardiac dysfunction (congestive heart failure, ischemia, arrhythmias)
- Diabetes
- Glaucoma
- Depression
- Impotence
Beta-adrenergic receptors (BARs) also play roles in development, behavior, cardiac function, smooth muscle tone, and metabolism.
Mice lacking the B1AR gene often die prenatally, and survivors exhibit abnormal cardiac function.
Thyroid hormones regulate B1AR density at the transcriptional level, modulated by the catecholamine-sensitive adenylyl cyclase system.
Regulation by cAMP has been linked to CRE modulator (CREM) family transcription factors in transformed cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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