Thermo Fisher Scientific Phospho-beta-1-Adrenoceptor (Thr404) Polyclonal Antibody
인산화된 Thr404 부위의 인간 베타-1 아드레날린 수용체를 인식하는 Rabbit Polyclonal 항체. Western blot에 최적화. 항원 친화 크로마토그래피로 정제. 1 mg/mL 농도의 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관.
- 카탈로그번호
- 7TM0028A
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human beta-1 around the phosphorylation site of Thr404 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Adrenergic receptors (ARs) are 7-transmembrane domain G-protein-coupled receptors that bind catecholamines such as epinephrine and norepinephrine.
Nine receptor subtypes have been identified: three alpha-1 ARs (1A/D, 1B, 1C), three alpha-2 ARs (2A, 2B, 2C), and three beta ARs (1, 2, 3).
ARs are involved in various physiological and pathological processes including:
- Hypertension
- Cardiac dysfunction (heart failure, ischemia, arrhythmia)
- Diabetes, glaucoma, depression, and impotence
Beta-1 adrenergic receptors (B1AR) play critical roles in cardiac function, development, and metabolism.
Knockout studies show that loss of the B1AR gene leads to prenatal lethality or abnormal cardiac function.
B1AR expression is regulated by thyroid hormones and the catecholamine-sensitive adenylyl cyclase system, with cAMP and CREM family transcription factors influencing its transcriptional control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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