Thermo Fisher Scientific Apolipoprotein B Polyclonal Antibody
Thermo Fisher Scientific의 Apolipoprotein B Polyclonal Antibody는 인간, 마우스, 랫트 시료에서 ApoB 단백질 검출에 적합합니다. Western blot 및 ICC/IF에 사용 가능하며, 고순도(>95%) 항체로 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein of human ApoB |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2803706 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
Apolipoprotein B (ApoB) is a major protein component of low-density lipoproteins (LDL) in human plasma, with a molecular mass of approximately 260–500 kDa. ApoB binds to specific cell membrane receptors, facilitating the removal of LDL and very low-density lipoprotein (VLDL) cholesterol from circulation.
LDL acts as the carrier protein for cholesterol in the blood and mediates uptake and clearance of cholesterol via LDL receptor binding. Oxidatively modified LDL is found in atherosclerotic lesions and is recognized by macrophages through scavenger receptors A and CD36. Elevated ApoB levels are associated with premature atherosclerosis.
ApoB exists in two major isoforms—ApoB-48 and ApoB-100—encoded by a single gene. ApoB-48 is produced through RNA editing of the ApoB-100 transcript, introducing a stop codon that results in a shorter protein. Mutations in the ApoB gene can cause disorders such as hypobetalipoproteinemia and hypercholesterolemia due to ligand-defective ApoB.
Normal plasma ApoB levels are approximately 800 mg/L.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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