Thermo Fisher Scientific APC2 Polyclonal Antibody
인간 APC2 단백질을 인식하는 Rabbit Polyclonal 항체로, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관됩니다. 세포 주기 조절 및 APC/C 복합체 연구에 유용합니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human APC2. Recombinant protein control fragment (Product #RP-98394) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662323 |
Product Specific Information
Immunogen sequence:
GQLSLLGSDVD GPSLAKAPIS APFVHEGLGV AVGGFPASRH GSPSRSARVP PFNYVPSPMV VAATTDSAAE K
Highest antigen sequence identity to the following orthologs:
- Mouse: 67%
- Rat: 77%
Target Information
Cell cycle–regulated protein ubiquitination and degradation within subcellular domains is essential for the normal progression of mitosis.
APC2 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle–regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.
APC/C degrades anaphase inhibitors, mitotic cyclins, and spindle-associated proteins, ensuring proper mitotic sequence.
APC/C component mRNA and protein levels are expressed at similar levels across most tissues and cell lines, suggesting they function as part of a complex.
Like APC11, APC2 contains cullin and RING finger domains important in regulating ubiquitination activity.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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