Thermo Fisher Scientific CD45RB (B-Cell Marker) Monoclonal Antibody (PTPRC/1132)
CD45RB 단백질을 표적으로 하는 인간 반응성 Mouse IgG1 단클론 항체. WB, IHC, ICC, Flow Cytometry 등 다양한 응용 가능. B세포 표지자로 사용되며 면역수용체 신호전달 및 세포 생존 경로 연구에 적합. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PTPRC/1132 |
| Immunogen | Human B-lymphocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Does not react with rat or monkey.
Target Information
CD45RB is a receptor-type protein tyrosine phosphatase belonging to the CD45 glycoprotein family.
CD45 plays a crucial role in lymphocyte development and antigen signaling, acting as a key regulator of Src-family kinases.
It promotes cell survival by modulating integrin-mediated signal transduction and participates in DNA fragmentation during apoptosis.
CD45 isoforms differ in extracellular domains but share identical transmembrane and cytoplasmic domains.
Their expression varies by cell type and physiological state.
CD45RB is expressed in microglia and inflammatory cells.
CD45 is expressed on human hematopoietic lineage cells except mature red blood cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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