Thermo Fisher Scientific CD163 Monoclonal Antibody (GHI/61), APC

Applications

• Flow Cytometry (Flow): 10 µL / 1×10⁶ cells
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Product Specifications

Additional Formats

• PE
• Request custom conjugation

Product Specific Information

This antibody binds hemoglobin-haptoglobin complex.

Target Information

CD163 (M130 antigen, Ber-Mac3, Ki-M8, SM4) is a 130 kDa membrane glycoprotein belonging to the scavenger receptor cysteine-rich superfamily. It acts as a receptor for the hemoglobin-haptoglobin complex, protecting tissues from oxidative damage and facilitating iron recycling. CD163 is expressed on human monocytes and macrophages, particularly in the late phase of inflammation.

Expression details:

• Present on all circulating monocytes and most tissue macrophages
• Absent in mantle zone and germinal center macrophages, interdigitating reticulum cells, and Langerhans cells
• Upregulated by IL-10, IL-6, and dexamethasone
• Shedding induced by LPS and PMA

CD163 binds hemoglobin/haptoglobin complexes in a calcium- and pH-dependent manner, showing higher affinity for multimeric haptoglobin (HP1F) complexes. It also triggers intracellular signaling involving tyrosine kinase-dependent calcium mobilization, inositol triphosphate production, and secretion of IL-6 and CSF1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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