Thermo Fisher Scientific CD163 Monoclonal Antibody (GHI/61), APC
인간 CD163 단백질을 인식하는 마우스 단클론 항체로 APC 형광체가 결합됨. Flow Cytometry용으로 최적화. 헤모글로빈-하프토글로빈 복합체에 결합. 4°C 암소 보관, 동결 금지.
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Applications
- Flow Cytometry (Flow): 10 µL / 1×10⁶ cells
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GHI/61 |
| Immunogen | Hairy cell leukemia cells |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2534503 |
Additional Formats
Product Specific Information
This antibody binds hemoglobin-haptoglobin complex.
Target Information
CD163 (M130 antigen, Ber-Mac3, Ki-M8, SM4) is a 130 kDa membrane glycoprotein belonging to the scavenger receptor cysteine-rich superfamily. It acts as a receptor for the hemoglobin-haptoglobin complex, protecting tissues from oxidative damage and facilitating iron recycling. CD163 is expressed on human monocytes and macrophages, particularly in the late phase of inflammation.
Expression details:
- Present on all circulating monocytes and most tissue macrophages
- Absent in mantle zone and germinal center macrophages, interdigitating reticulum cells, and Langerhans cells
- Upregulated by IL-10, IL-6, and dexamethasone
- Shedding induced by LPS and PMA
CD163 binds hemoglobin/haptoglobin complexes in a calcium- and pH-dependent manner, showing higher affinity for multimeric haptoglobin (HP1F) complexes. It also triggers intracellular signaling involving tyrosine kinase-dependent calcium mobilization, inositol triphosphate production, and secretion of IL-6 and CSF1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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