Thermo Fisher Scientific MLH3 Recombinant Rabbit Monoclonal Antibody (6H7J5)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

6H7J5

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1190-1389 of human MLH3. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MLH3,uniProtId:Q9UHC1-1,ncbiNodeId:9606,antigenRange:1190-1389,antigenLength:1453,antigenImageFileName:MA5-55489_MLH3_Q9UHC1-1_Rabbit.svg,antigenImageFileNamePDP:MA5-55489_MLH3_Q9UHC1-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.09 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Immunogen Sequence: QVLQQVDNKF IACLMSTKTE ENGEAGGNLL VLVDQHAAHE RIRLEQLIID SYEKQQAQGS GRKKLLSSTL IPPLEITVTE EQRRLLWCYH KNLEDLGLEF VFPDTSDSLV LVGKVPLCFV EREANELRRG RSTVTKSIVE EFIREQLELL QTTGGIQGTL PLTVQKVLAS QACHGAIKFN DGLSLQESCR LIEALSSCQL

Target Information

This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.