Thermo Fisher Scientific MLH3 Recombinant Rabbit Monoclonal Antibody (6H7J5)
MLH3 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot 및 ELISA에 최적화됨. 인간, 생쥐, 랫트 반응성. Protein A로 정제된 액상 항체이며, -20°C에서 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:6,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 6H7J5 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1190–1389 of human MLH3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.09 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Immunogen Sequence:
QVLQQVDNKF IACLMSTKTE ENGEAGGNLL VLVDQHAAHE RIRLEQLIID SYEKQQAQGS GRKKLLSSTL IPPLEITVTE EQRRLLWCYH KNLEDLGLEF VFPDTSDSLV LVGKVPLCFV EREANELRRG RSTVTKSIVE EFIREQLELL QTTGGIQGTL PLTVQKVLAS QACHGAIKFN DGLSLQESCR LIEALSSCQL
Target Information
This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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