Thermo Fisher Scientific MDM4 Monoclonal Antibody (OTI4E10), TrueMAB
Human MDM4 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot 및 Immunocytochemistry에 최적화됨. Lyophilized 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용 가능. 연구용으로 p53 경로 조절 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4E10 |
| Immunogen | Full length human recombinant protein of human MDM4 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The MDM2 protein regulates p53 protein stability. MDMX (also known as MDM4) inhibits MDM2-mediated degradation of p53 through distinct interactions with MDM2.
The MDMX gene is often amplified in malignant gliomas. ARF interacts with MDMX to sequester it within the nucleolus, resulting in increased p53 transactivation.
MDMX expression can counteract MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation.
Like MDM2, MDMX also binds and stabilizes p73, increasing its half-life.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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