Thermo Fisher Scientific RBMXL2 Recombinant Rabbit Monoclonal Antibody (2Z6C10)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen Sequence:
GGMRGRALAV RGRDGYSGPP RREPLPPRRD PYLGPRDEGY SSRDGYSSRD YREPRGFAPS PGEYTHRDYG HSSVRDDCPL RGYSDRDGYG GRDRDYGDHL SRGSHREPFE SYGELRGAAP GRGTPPSYGG GGRYEEYRGY SPDAYSGGRD SYSSSYGRSD RYSRGRHRVG RPDRGL

Target Information

The hnRNPs are RNA-binding proteins that complex with heterogeneous nuclear RNA (hnRNA). They are associated with pre-mRNAs in the nucleus and influence pre-mRNA processing and mRNA metabolism and transport. While most hnRNPs are nuclear, some shuttle between the nucleus and cytoplasm. RBMXL2 contains two RRM domains that bind RNAs and shares similarity with HNRPG and RBMY proteins. It may replace HNRPG function during meiotic prophase or act as a germ cell-specific splicing regulator. RBMXL2 primarily localizes to the nuclei of meiotic spermatocytes and is a candidate gene for autosomal male infertility. This gene belongs to the HNRPG subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.