Thermo Fisher Scientific RALA Recombinant Rabbit Monoclonal Antibody (3G8D7)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

3G8D7

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 120-206 of human RalA. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:RALA,uniProtId:P11233-1,ncbiNodeId:9606,antigenRange:120-206,antigenLength:206,antigenImageFileName:MA5-55544_RALA_P11233-1_Rabbit.svg,antigenImageFileNamePDP:MA5-55544_RALA_P11233-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Immunogen Sequence: VPFLLVGNKS DLEDKRQVSV EEAKNRAEQW NVNYVETSAK TRANVDKVFF DLMREIRARK MEDSKEKNGK KKRKSLAKRI RERCCIL

Target Information

Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.