Thermo Fisher Scientific CCR8 Polyclonal Antibody
CCR8 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인체 시료에 반응하며 IHC(P) 실험에 적합. 항원 친화 크로마토그래피로 정제된 액상 제품. 단기 4°C, 장기 -20°C 보관 권장. 연구용 전용 시약.
- 카탈로그번호
- PA533404
- 판매단위
- pk
카탈로그
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Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 22 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 19 amino acid peptide from C-terminus of human CCR8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550784 |
Product Specific Information
Percent identity with other species by BLAST analysis:
- Human (100%)
- Gorilla (95%)
- Gibbon, Monkey (89%)
- Marmoset (84%)
Target Information
CCR8 encodes a member of the beta chemokine receptor family, predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are crucial for the migration of various cell types to inflammatory sites.
This receptor protein is preferentially expressed in the thymus. Ligands identified for CCR8 include I-309, thymus activation-regulated cytokine (TARC), and macrophage inflammatory protein-1 beta (MIP1β).
Studies indicate CCR8’s role in regulating monocyte chemotaxis and thymic cell apoptosis, contributing to the positioning of activated T cells within antigenic challenge sites and lymphoid tissues.
CCR8 expression has been reported in spleen, thymus, natural-killer cells, monocytes, and T cells, and at lower levels in peripheral blood leukocytes.
This gene is located in the chemokine receptor gene cluster region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-33404_CCR8_P51685-1_Rabbit.svg, PA5-33404_CCR8_P51685-1_Rabbit_PDP.jpeg)
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