Thermo Fisher Scientific APE1 Polyclonal Antibody
Thermo Fisher Scientific의 APE1 Polyclonal Antibody는 인간을 포함한 여러 종에 반응하며, DNA 손상 복구 및 산화 신호 조절 연구에 적합합니다. Western blot과 IHC에 사용 가능하며, 고순도 액상 형태로 제공됩니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- PA19007
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific APE1 Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 0.1–0.3 µg/mL
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 4–6 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the N terminus amino acids PKRGKKGAVAEDGD (aa 2–16) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2057930 |
Product Specific Information
- Predicted to react with bovine, canine, and porcine based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 16,000.
Target Information
Mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is a multifunctional enzyme crucial for DNA repair and redox regulation.
APE repairs abasic sites in DNA and modulates the redox state of proteins involved in oxidative signaling and transcription factor regulation (Fos, Jun, NF-kB, Myb, HIF-1α, CREB, Pax), cell cycle control (p53), and apoptosis.
Abasic sites arise from spontaneous loss or oxidative damage, chemotherapy, ionizing radiation, UV irradiation, and DNA glycosylase activity.
APE expression varies by tissue and developmental stage, showing diverse subcellular localization and interactions.
Regulation by phosphorylation occurs partly through casein kinase II.
Increased APE levels are observed upon reoxygenation of hypoxic cells and in some malignancies, while decreased expression is linked to apoptosis induction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.