Thermo Fisher Scientific Androgen Receptor Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Predicted to react with bovine, canine, mouse, porcine, and rat based on sequence homology.
• Tested in Peptide ELISA: antibody detection limit dilution 64,000.

Target Information

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It is a >90 kDa protein with three major functional domains:

• N-terminal domain
• DNA-binding domain
• Androgen-binding domain

AR acts as a ligand-activated transcription factor binding testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, it dissociates from accessory proteins, translocates to the nucleus, dimerizes, and activates transcription of androgen-responsive genes.

The AR signaling pathway is crucial for the development and function of male reproductive organs such as the prostate and epididymis, and also influences nonreproductive tissues like muscle, hair follicles, and brain. AR regulates MAP kinase activity, and MEK1/2 pathway inhibition affects AR phosphorylation. Dysregulation of AR signaling is linked to prostate cancer, Kennedy’s disease, and male infertility. Mutations in the AR gene cause complete androgen insensitivity syndrome (CAIS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.