Thermo Fisher Scientific Androgen Receptor Polyclonal Antibody
Androgen receptor 인식 polyclonal antibody로 Western blot, IHC, ICC, ChIP 등 다양한 응용 가능. Human에 반응하며 bovine, mouse 등에서도 예측 반응. 0.5 mg/mL 농도의 액상 제품으로 -20°C 보관. 연구용으로만 사용.
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 2–3 µg/mL |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| ChIP assay (ChIP) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the N terminus amino acids EVQLGLGRVYPRPPSC (aa 2–16) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2060163 |
Product Specific Information
- Predicted to react with bovine, canine, mouse, porcine, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 64,000.
Target Information
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. It is a >90 kDa protein with three major functional domains:
- N-terminal domain
- DNA-binding domain
- Androgen-binding domain
AR acts as a ligand-activated transcription factor binding testosterone (T) and dihydrotestosterone (DHT). Upon ligand binding, it dissociates from accessory proteins, translocates to the nucleus, dimerizes, and activates transcription of androgen-responsive genes.
The AR signaling pathway is crucial for the development and function of male reproductive organs such as the prostate and epididymis, and also influences nonreproductive tissues like muscle, hair follicles, and brain. AR regulates MAP kinase activity, and MEK1/2 pathway inhibition affects AR phosphorylation. Dysregulation of AR signaling is linked to prostate cancer, Kennedy’s disease, and male infertility. Mutations in the AR gene cause complete androgen insensitivity syndrome (CAIS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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