Thermo Fisher Scientific SRPK2 Polyclonal Antibody
SRPK2 단백질 인산화 연구용 Rabbit Polyclonal 항체로, Human에 반응합니다. IHC 및 IHC(P)에서 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. HBV 감염 및 신경세포 아폽토시스 연구에 적합합니다.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:50–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 425 and 475 of Human SFRS protein kinase 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Bovine, Dog, Horse, Rabbit, Pig, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, and Northern white-cheeked gibbon.
Target Information
SRPK2, along with SRPK1, is likely the cellular protein kinase mediating HBV core protein phosphorylation during viral infection, representing a potential host target for therapeutic intervention.
It promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression through phosphorylation of SRSF2, which suppresses p53/TP53 phosphorylation. This relieves p53/TP53’s repressive effect on cyclin-D1 expression.
SRPK2 also phosphorylates ACIN1, redistributing it from nuclear speckles to the nucleoplasm, leading to cyclin A1 up-regulation. It plays an essential role in spliceosomal B complex formation via phosphorylation of DDX23/PRP28 and negatively regulates HBV replication by reducing pregenomic RNA packaging efficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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