Thermo Fisher Scientific Activin A Polyclonal Antibody
Activin A 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot 및 SPR 분석에 사용 가능. 인간과 설치류 시료에 반응하며, 고순도의 친화 크로마토그래피 정제 제품. 0.5 mg/mL 액상 형태로 제공되며, PBS와 sucrose buffer에 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 0.2–1 µg/mL
Surface Plasmon Resonance (SPR)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human INHBA (aa 35–84) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2609617 |
Product Specific Information
Peptide sequence:
CPSCALAALP KDVPNSQPEM VEAVKKHILN MLHLKKRPDV TQPVPKAALL
Sequence homology:
Cow: 100%
Dog: 93%
Goat: 100%
Horse: 100%
Human: 100%
Mouse: 100%
Pig: 100%
Rabbit: 93%
Rat: 100%
Sheep: 100%
Target Information
Activins are dimeric growth and differentiation factors belonging to the transforming growth factor-beta (TGF-beta) superfamily. They signal through a heteromeric complex of receptor serine kinases, including type I (I and IB) and type II (II and IIB) receptors. These receptors are transmembrane proteins with extracellular ligand-binding, transmembrane, and cytoplasmic kinase domains. Type I receptors are essential for signaling, while type II receptors are required for ligand binding and type I receptor expression. Upon ligand binding, type I receptors are phosphorylated by type II receptors, initiating downstream signaling.
Mutations in Activin A are associated with fibrodysplasia ossificans progressiva.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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