Thermo Fisher Scientific SIGLEC12 Monoclonal Antibody (750620)
Mouse Siglec-E 단백질을 표적으로 하는 Rat IgG2b 형 단클론 항체입니다. Flow Cytometry에 적합하며, Lyophilized 형태로 제공됩니다. Protein A/G로 정제되었으며 PBS 및 5% trehalose buffer에 재구성하여 사용합니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific SIGLEC12 Monoclonal Antibody (Clone 750620)
Applications
- Flow Cytometry (Flow)
Tested Dilution: 2.5 µg per million cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 750620 |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse Siglec-E (Gln19–Phe354) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2606302 |
Product Specific Information
Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.
Target Information
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are cell surface proteins of the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to sialic acid moieties on glycolipids and glycoproteins.
This gene encodes a member of the SIGLEC3-like subfamily, characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set domains and cytoplasmic tyrosine-based motifs (ITIM and SLAM-like). Upon tyrosine phosphorylation, the protein recruits SHP1 and SHP2 phosphatases, functioning as an inhibitory receptor in macrophage signaling.
Located on chromosome 19q13.4, this gene forms a cluster with other SIGLEC3-like genes. Alternative splicing produces distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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