Thermo Fisher Scientific CRYBB2 Polyclonal Antibody
인간 CRYBB2 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS, 40% 글리세롤, 0.02% sodium azide 용액에 보관. 단기 4°C, 장기 -20°C 보관 권장.
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- PA560496
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CRYBB2. Recombinant protein control fragment (Product #RP-99590) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2640179 |
Product Specific Information
Immunogen sequence: IIDDDVPSFH AHGYQEKVSS VWVRSG
Highest antigen sequence identity to orthologs:
- Mouse: 88%
- Rat: 88%
Target Information
Crystallins are separated into two classes: taxon-specific (enzyme) and ubiquitous. The ubiquitous class constitutes the major proteins of vertebrate eye lens, maintaining transparency and refractive index.
Lens central fiber cells lose their nuclei during development, so crystallins are synthesized once and retained throughout life, resulting in extremely stable proteins.
Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins also form a superfamily. Alpha and beta families are further divided into acidic and basic groups.
Beta-crystallins, the most heterogeneous, differ by the presence of a C-terminal extension (present in the basic group, absent in the acidic group). They form aggregates of various sizes, self-associate to form dimers, or form heterodimers with other beta-crystallins.
This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B3. A chain-terminating mutation has been associated with type 2 cerulean cataracts.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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